What happens to the set of proteins circulating in the blood when a transgender person begins feminizing hormone therapy? An international team led from the Murdoch Children’s Research Institute...
Can gender-affirming hormone treatment modify the personality traits of a transgender person? A recent study, published in 2026 in the journal Comprehensive Psychoneuroendocrinology, addresses this qu...
A new review study published in 2026 in the journal Journal of Pediatric Urology (Elsevier) analyzes the relationship between congenital adrenal hyperplasia and gender dysphoria. Congenital adrenal hy...
The biological basis of gender incongruence remains a mystery, but the accumulated evidence points to hormonal and environmental factors acting during fetal development as potentially playing a releva...
A study published in 2026 in the journal Scientific Reports (from the Nature group) offers new data on the brain activity of transgender women, a group for which neuroscientific evidence remains scarc...
The voice is one of the most visible markers of gender identity, and having it align with each person’s lived gender profoundly influences their psychological well-being. A new study published i...
Sex hormones influence many bodily processes beyond sexual characteristics, and one of the most relevant is insulin sensitivity—that is, the ability of cells to respond to this hormone and take up glu...
Hormone therapy is one of the cornerstones of gender-affirming treatment in people with gender incongruence, but many questions remain open about its medium- and long-term effects on health. A team fr...
A new study published in 2026 in the journal Dialogues in Clinical Neuroscience provides one of the most detailed descriptions to date of how brain circuits are organized in people with gender incongr...
Research published in 2026 in Communications Psychology (Nature Portfolio) examines how knowledge about the development of gender identity influences support for the autonomy of transgender minors and...
An epigenome-wide association study (EWAS) published in Frontiers in Neuroscience by the group of Rosa Fernández, Eduardo Pásaro and Antonio Guillamón shows that people with gender incongruence presen...
A multicenter longitudinal study presented in early 2026 analyzes the structural brain changes during the first six months of gender-affirming hormone therapy in a sample of 43 transgender people. The...
A review published in Anales de Pediatría (Elsevier), with the participation of researcher Rosa Fernández among its authors, addresses a central question in the scientific and clinical debate: whether...
A network meta-analysis published in 2026 in the International Journal of Transgender Health has analyzed the length of the polymorphic CAG repeat of the androgen receptor (AR) gene in transgender and...
An experimental investigation published in the International Journal of Molecular Sciences by the group of Guillamón, Pásaro and Fernández, together with researchers from the University of A Coruña, h...
A case series published in 2026 in the Journal of Pediatric Endocrinology and Metabolism describes three cases with genetic confirmation of 17β-hydroxysteroid dehydrogenase type 3 deficiency (HSD17B3)...
Published in Frontiers in Endocrinology, this study by the Spanish group of Rosa Fernández and Eduardo Pásaro analyzes single nucleotide polymorphisms (SNPs) in the metabotropic glutamate receptors (m...
A new study published in 2026 in the journal Neuroscience has examined cortical structure and brain size in transfeminine individuals from Thailand, comparing them with cisgender men and women. It is ...
A hypothesis article published in Journal of Neuroendocrinology by the group of Guillamón, Fernández and Pásaro (UNED and University of A Coruña) proposes an integrative framework for how feminizing h...
Genetic research on sexual orientation and gender identity generates disproportionate public interest given how little is still known. A study published in 2026 in Behavior Genetics has attempted to a...
A multidisciplinary team from the sex neuroscience group, made up of researchers from the Universidad Nacional de Educación a Distancia (UNED) and the University of A Coruña —including Drs. Antonio Gu...
A systematic review published in Behavior Genetics (Springer) synthesizes the literature on twin studies concerning gender diversity, with the aim of quantifying the relative contribution of genetic a...
A genetic study published in Sexual Development (Karger) analyzes rare variants in cell adhesion molecule (CAM) genes in transgender men and suggests a possible role in gender dysphoria. Cell adhesion...
Published in Scientific Reports, this study employs the twin design to disentangle the contribution of genetic inheritance and intrauterine hormonal factors to transgender and gender diverse identitie...
Published in Sexual Medicine, this study employs whole exome sequencing (WES) to identify genetic susceptibility loci in transgender individuals, a step toward the molecular characterization of the bi...