Most debates about puberty blockers focus on two things: mental health and bone density. But there is a question that worries many families and adolescents and that is hardly ever discussed: what happ...
Gender-affirming hormone therapy visibly changes the body of transgender women, but what happens inside, at the molecular level, had remained largely a mystery. An international team has this time loo...
Gender dysphoria remains a largely unexplored territory for neurobiology. One of the most promising avenues runs through oxytocin, a neuropeptide known for modulating social cognition and emotional pr...
The brain pattern that has been linked to gender identity in trans women is not exclusive to Europe or the United States. A new study carried out in Thailand confirms that this cortical phenotype repe...
That many people with gender dysphoria describe trouble concentrating is not just a subjective impression. A new study suggests that this distress may be physically «wired» through a speci...
The hippocampus, that brain region central to memory and emotion, responds to sex hormones. And in transgender people receiving gender-affirming hormone therapy, that response becomes a window into ho...
Is the brain of a transgender person more similar to the sex assigned at birth, or to the gender they identify with? It is one of the central questions in the neuroscience of gender dysphoria, and a n...
A new multicenter study conducted in Canada has analyzed what happens to the gender identity of adolescents who attend specialized clinics for gender dysphoria. The main conclusion: the vast majority ...
Can certain genes explain part of gender dysphoria? Genetics has spent years trying to answer this question and accumulating clues. The latest comes from a Turkish team, which analyzed the DNA of a gr...
A new study, funded by the World Health Organization, has brought together the available evidence on healthcare for adults with gender incongruence. The main conclusion is clear: the medical care thes...
In the collective imagination, breast cancer is almost always associated with a particular patient profile. But the clinical reality is much broader and, for years, data on this disease in transgender...
The human body does not treat testosterone and oestradiol as mere messengers of reproduction: these hormones travel throughout the organism and also communicate with the immune system. A group of rese...
On average, how long does a transgender person live compared with the rest of the population? Until now, the answers were based mainly on small studies or studies from specific countries. A new nation...
What happens to the mental health of adolescents who attend specialised gender identity services? A nationwide study carried out in Finland, published in Acta Paediatrica, has analysed medical records...
For a long time, sex has been discussed as if it were a switch that can only be in two positions. The genetics of development, however, tells a more nuanced story. An international team coordinated by...
Gender-affirming hormone therapy has been the subject of debate for years, and one of the questions that most concerns the medical community is its effect on the heart and blood vessels. New research ...
Adolescence is the critical window in which most of the bone mass of a lifetime is accumulated. That is why any treatment that interferes with this process raises legitimate doubts. A new meta-analysi...
During adolescence, the body experiences one of the greatest hormonal reorganizations of life. For young people with gender dysphoria, that process can become an intense source of distress. A question...
Could genetics have something to do with gender identity? For decades it was an almost taboo question, but science has been gathering clues for years. A recent study published in Scientific Reports (a...
What happens to the set of proteins circulating in the blood when a transgender person begins feminizing hormone therapy? An international team led from the Murdoch Children’s Research Institute...
Can gender-affirming hormone treatment modify the personality traits of a transgender person? A recent study, published in 2026 in the journal Comprehensive Psychoneuroendocrinology, addresses this qu...
A new review study published in 2026 in the journal Journal of Pediatric Urology (Elsevier) analyzes the relationship between congenital adrenal hyperplasia and gender dysphoria. Congenital adrenal hy...
The biological basis of gender incongruence remains a mystery, but the accumulated evidence points to hormonal and environmental factors acting during fetal development as potentially playing a releva...
A study published in 2026 in the journal Scientific Reports (from the Nature group) offers new data on the brain activity of transgender women, a group for which neuroscientific evidence remains scarc...
The voice is one of the most visible markers of gender identity, and having it align with each person’s lived gender profoundly influences their psychological well-being. A new study published i...
Sex hormones influence many bodily processes beyond sexual characteristics, and one of the most relevant is insulin sensitivity—that is, the ability of cells to respond to this hormone and take up glu...
Hormone therapy is one of the cornerstones of gender-affirming treatment in people with gender incongruence, but many questions remain open about its medium- and long-term effects on health. A team fr...
A new study published in 2026 in the journal Dialogues in Clinical Neuroscience provides one of the most detailed descriptions to date of how brain circuits are organized in people with gender incongr...
Research published in 2026 in Communications Psychology (Nature Portfolio) examines how knowledge about the development of gender identity influences support for the autonomy of transgender minors and...
An epigenome-wide association study (EWAS) published in Frontiers in Neuroscience by the group of Rosa Fernández, Eduardo Pásaro and Antonio Guillamón shows that people with gender incongruence presen...